Pathophysiology : Disease Analysis

Discussion 2: Disease Analysis Journal


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When you are faced with a medical case and do not know how to approach it or have questions, what do you do? Even experienced nurses, dentists, doctors, and pharmacists will go to their smartphones and begin searching for answers. So much information is available. How do you know what information is reliable and valid? The purpose of the journal assignment is for you to practice finding, evaluating, and summarizing resources around key concepts that are presented throughout the module, which are relevant to your specific area of interest. This journal should be valuable to you; you can collect sites, resources, and readings that you find helpful to your learning.

This module will focus on the following topics that examine how our body responds, or rather adapts, to environmental toxins on a cellular level:

        -Cellular adaption and neoplasia

        -Infection, immunity, and inflammation

        –Hematological disorders

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You should spend approximately 10 hours on this assignment.


1. From the list of selected readings below, choose two with topics that you know the least about or are most interesting to you.

2. Then search for, read, and incorporate other readings of your choice in your area of interest that focus on cellular adaption and neoplasia; infection, immunity, and inflammation; and/or hematological disorders. You might include:

        -1-2 journal articles or websites

        -Book chapters (past textbooks may be good options)

        -Your goal is to have a total of at least 60 pages of content read. 

3. Your summary of each reading should be at least one paragraph (100-200 words) and include the following information:

        -All references must be cited using APA Style format.

        -Number of pages read

        -Keywords you used to find the reading

        -Link to the reading

        -Why you selected the reading

        -Main point of the reading

        -Describe how the health deviations you read about alter normal physiology.

        -Provide your key takeaway from the reading. This could be something that made you pause, changed your thinking, supported your thinking, or made you question something.

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4. Build your journal in a Word document. You will build on this document in each module. (Do not start a new journal document for each module.) By the end of the course, you will have all five journal assignments in one single document.

5. Attach your Word document to a post in the Module 1 Discussion
2: Disease Analysis Journal discussion board.

In your post, respond to the following questions: How do you know that the material you have found and read is reliable? How do you know that it is valid? 


It may be helpful to review your classmates’ articles to see which keywords they are using to find their content. We want to build a community of learners who share great resources and readings. If you see an article that interests you, feel free to read it!

Selected Readings (login id: s02376483)

Choose two readings. All readings are available through the CCCOnline Library in CINAHL Plus With Full Text.

1. Badr, M., Hassan, T., Sakr, H., Karam, N., Rahman, D. A., Shahbah, D., Zakaria, M., & Fehr, S. (2016). Chemotherapy induced neutropenia among pediatric cancer patients in Egypt: Risks and consequences. Molecular & Clinical Oncology, 5(3), 300–306.


2. Baron, V.T., Pio, R., Jia, Z. & Mercola, D. (2015). Early growth response 3 regulates genes of inflammation and directly activates IL6 and IL8 expression in prostate cancer. British Journal of Cancer, 12: 755-764. doi: 10.1038/bjc.2014.622


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3. Carvalho, M. I., Silva-Carvalho, R., Pires, I., Prada, J., Bianchini, R., Jensen-Jarolim, E., & Queiroga, F. L. (2016). A comparative approach of tumor-associated inflammation in mammary cancer between humans and dogs. Biomed Research International, 1-12. doi:10.1155/2016/4917387


4. Epstein, S.P., Chen, D., Asbel, P.A. (2009) Evaluation of Biomarkers of Inflammation in Response to Benzalkonium Chloride on Corneal and Conjunctival Epithelial Cells. Journal of Ocular Pharmacology and Therapeutics, 25(5): 415-42. doi: 10.1089/jop.2008.0140


5. Ferguson, J.F., Patel, P.N., Shah, R.Y., Mulvey, C.K., Gadi, R., Nijjar, P.S., Usman, H.M., Mehta, N.N., Shah, R., Master, S.R., Propert, K.J. & Reilly, M.P. (2013). Race and gender variation in response to evoked inflammation. Journal of Translational Medicine. 11(1): 63-63.


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6. Miceli, T., Lilleby, K., Noonan, K., Kurtin, S., Faiman, B. & Mangan, P.A. (2013). Autologous Hematopoietic Stem Cell Transplantation for Patients With Multiple Myeloma. Clinical Journal of Oncology Nursing, 17: 13-24. doi: 10.1188/13.CJON.S2.13-243


7. Mohammad-Shahi, M., Mowl, K., Haidari, M., Zarei, M., & Choghakori, R. (2016).  Soy milk consumption, markers of inflammation and oxidative stress in women with rheumatoid arthritis:  A randomized cross-over clinical trial. Nutrition & Dietetics, 73: 139-145. doi: 10.1111/1747-0080.12174


8. Rascon, J., Rageliene, L., Stankeviciene, S., Palionis, D., Tamosiunas, E.E., Valeviciene, N., Zvirblis, T. (2014). An assessment of iron overload in children treated for cancer and nonmalignant hematologic disorders. European Journal of Pediatrics, 173:1137–1146. doi 10.1007/s00431-014-2295-5


9. Rescigno, T., Micolucci, L., Tecce, M.F., Capasso, A. (2017). Bioactive Nutrients and Nutrigenomics in Age-Related Diseases. Molecules, 22(1), 105.


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10. Timmons, B.W. & Raha, S. (2008). A pediatric perspective on inflammation and oxidative stress in response to exercise. Applied Physiology, Nutrition & Metabolism, 33(2): 411-419.


11. Toprak, B., Yalcin, H.Z. & Colak, A. (2014). Vitamin B12 and folate deficiency: should we use a different cutoff value for hematologic disorders? International Journal of Laboratory Hematology, 36: 409–414. doi: 10.1111/ijlh.12158


12. Yetgin, S. & Elmas, S.A. (2010). Parvovirus-B19 and hematologic disorders. Turkish Journal of Hematology, 27: 224-33. doi: 10.5152/tjh.2010.43

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