Oral drug administration is the most commonly used route due to many Essay

Oral drug administration is the most commonly used route due to many advantages that can be driven from it which are higher patient compliance, lower pain, ease of administration and decrease levels of infection(1).1.Colon targetingDelivering drugs to their site of action leads to lower side effects and to increase pharmacological action. Colon becomes one of the most interesting areas to be targeted through oral route)(2). Colon related diseases such as Crohn’s disease, ulcerative colitis, inflammatory bowel disease, colorectal cancer, and many others have taken a huge interest in their treatment that can be achieved by colon targeting.

Colon-targeted drug delivery systems provide potential advantages like delivery of high local drug concentration at the impaired part of the colon to produce optimum therapeutic action and reduction in systemic adverse effects associated with the premature release and subsequent absorption of drugs from the upper gastrointestinal tract this differentiates it from the classical oral dosage forms(3). 1.1 Systems developed for colon-specific drug deliverycovalent linkage of a drug with a carrier, time-dependent release systems, coating with pH-sensitive polymers and enzymatically controlled delivery systems which is also called a (microbially triggered system) are Various systems that have been developed for colon-specific drug delivery(2).

Don't use plagiarized sources. Get Your Custom Essay on
Oral drug administration is the most commonly used route due to many Essay
From as low as $9/Page
Order Essay

Each system of these systems has its own drawbacks, pH-sensitive systems may lose site specificity of drug release because of similar pH values of small intestinal and colonic fluids, time-dependent system has difficulty for accurate prediction of site for drug release because of wide variation in gastric retention time also Microbially triggered systems are affected by factors that may change the composition of the human gut ecosystem and a larger amount of coat is required to prevent premature drug release due to higher hydrophilicity of the polysaccharides(3). The union of two or more systems has shown great results regarding colon-specific drug release leading to minimal drug release in the stomach and small intestine and huge amount of drug released in the colon(4).1.2. Compression coatingFilm coating or compression coating processes are the processes that have been used for colon drug delivery system. Compression coating is a solvent-free process which is safe and inexpensive and it has higher stability when compared to film coating, but it undergoes disadvantages like the requirement of highly skilled persons, and it needs more care during compression to avoid compression-related problems(5).Compression -coated tablets as colonic release systems are usually obtained by coating the drug cores by compression-coating. The coating polymers are classified into soluble or insoluble matrix-forming polymers, capable of controlling drug release by either matrix dissolution or erosion. Examples for these polymers are polysaccharides which control drug release through their enzymatic degradation by the colonic microflora or enteric polymers, which are insoluble in acidic media but dissolve in slightly acid to neutral pH environments(6). 1.3. Soluble forming polymersHydrophilic polymers are highly used in formulating oral controlled-release tablets(1).1.3.1. Hydroxypropyl methylcellulose and hydroxypropyl celluloseHydroxypropyl methylcellulose and hydroxypropyl cellulose are the most often used polymers In the development and production of hydrophilic matrix tablets, these polymers on the surface of the dosage form hydrates and swells once hydrophilic matrix dosage form reached the gastrointestinal tract forming a protective gel layer from which the drug is gradually and continuously released over time. Considering the solubility interplay between the drug and polymer, the release is diffusion-controlled if the solubility of the incorporated drug is greater than the solubility of the polymeric matrix. In contrast, the release is more erosion-controlled if the solubility of the polymeric matrix is greater than the solubility of the incorporated drug(7). Pectin, chondroitin sulfate, amylase, guar gum, xanthan gum ,and chitosan are examples of polysaccharides that are being examined as carriers for colon-specific drug delivery(3). 1.3.2. PolysaccharidesThere are large amounts of polysaccharides that are present in the human colon as the colon is inhabited by a numerous bacteria which secrete many enzymes e.g amylase, pectinase, xylanase, etc(8). Major approaches utilizing polysaccharides for colon-specific delivery are a fermentable coating of the drug core, embedding of the drug in the biodegradable matrix and formulation of drug saccharine conjugate(1).1.4. KetoprofenKetoprofen belongs to nonsteroidal anti-inflammatory drug it is used as an analgesic and anti-inflammatory drug for the treatment of pain and rheumatic diseases. Ketoprofen is considered a good candidate for colon delivery due to the well known gastric side effect. Therefore, there are several research works that studied the strategies of oral administration and colon-specific release of ketoprofen(6).

The Homework Writings
Order NOW For A 10% Discount!
Pages (550 words)
Approximate price: -

Our Advantages

Plagiarism Free Papers

All our papers are original and written from scratch. We will email you a plagiarism report alongside your completed paper once done.

Free Revisions

All papers are submitted ahead of time. We do this to allow you time to point out any area you would need revision on, and help you for free.


A title page preceeds all your paper content. Here, you put all your personal information and this we give out for free.


Without a reference/bibliography page, any academic paper is incomplete and doesnt qualify for grading. We also offer this for free.

Originality & Security

At thehomeworkwritings.com, we take confidentiality seriously and all your personal information is stored safely and do not share it with third parties for any reasons whatsoever. Our work is original and we send plagiarism reports alongside every paper.

24/7 Customer Support

Our agents are online 24/7. Feel free to contact us through email or talk to our live agents.

Try it now!

Calculate the price of your order

We'll send you the first draft for approval by at
Total price:

How it works?

Follow these simple steps to get your paper done

Place your order

Fill in the order form and provide all details of your assignment.

Proceed with the payment

Choose the payment system that suits you most.

Receive the final file

Once your paper is ready, we will email it to you.

Our Services

We work around the clock to see best customer experience.


Flexible Pricing

Our prices are pocket friendly and you can do partial payments. When that is not enough, we have a free enquiry service.


Admission help & Client-Writer Contact

When you need to elaborate something further to your writer, we provide that button.


Paper Submission

We take deadlines seriously and our papers are submitted ahead of time. We are happy to assist you in case of any adjustments needed.


Customer Feedback

Your feedback, good or bad is of great concern to us and we take it very seriously. We are, therefore, constantly adjusting our policies to ensure best customer/writer experience.