1. The collapse of the world trade centre towers in New York City on September 11, 2001 (9/11), released more than a million tons of debris and dust into the surrounding area. In response, 15 years later, Congress authorized the James Zadroga 9/11 Health and Compensation Act, a law designed to respond to the adverse health effects of the disaster. One of the major health toxins associated with the WTC is methyl isocyanate.

– What are some of the health risks associated with workers who helped with clean up after 9/11 and may have been exposed to this toxin? (5 points)

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– Specifically, discuss the signalling pathway involved in this toxins reactivity. Why is it so dangerous? (15 points)

– What adverse health effects does it have? Why is it considered a universal poison? (5 points)

2. What role does the ECM play in cellular coordination of events? Be specific and give structure/function relationships. (10-points)

– What is the biological significance of ECM components in pathological conditions like cancer? Give a specific example. (10-points)

– Using the literature, describe one drug and /or drug design that could be used to combat the abnormal signaling that takes places in cancer through ECM. How does this drug work? Why would or is it effective? (5 points)

3. The cell cycle is a precisely programmed series of events that enables a cell to duplicate its contents and to divide into two daughter cells. This series of events is controlled by the machinery that is often termed the cell cycle clock.

– What molecular mechanisms operate to ensure that once the decision to advance through the restriction points have been made, this leads to essentially irreversible commitment to complete the remaining phases of the cell cycle through M phase. (5 points) For more information on Biology check on this:

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